Pharmacogenomics (PGx): the way to Precision Medicine

Instructor

Nourtan Abdeltawab

Assistant Professor

Dr Nourtan Abdeltawab has more than 10 years’ experience in systems biology and genome-wide association studies (GWAS) of infectious diseases. She received her doctoral degree in systems biology of immunogenetics of infectious diseases from the University of Tennessee Health Science Center in Memphis, TN, USA in 2010 and continued postdoctoral training at the University of Cincinnati in Ohio, USA until 2012. Using GWAS she mapped quantitative trait loci (QTLs) modulating differential host responses to a number of infectious diseases including streptococcal sepsis, candidiasis, pneumonia, and Ebola. She has also worked on genome-wide transcriptional profiling projects, including mouse spleen (for more than 100 recombinant inbred mouse strains) and a human genome diversity cell line panel (CEPH panel). Dr Abdeltawab is currently Assistant Professor of microbiology and immunology, Cairo University, Faculty of Pharmacy. She is L’Oréal-UNESCO FWIS International Rising Talent fellow 2015.

Reviews (1)

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Overview

 

Pharmacogenomics (PGx):

 

 Concepts and Practice

 

 

Two days intensive interactive workshop on introduction to pharmacogenomics and precision medicine 

 

Workshop Trainer – Dr. Nourtan F. Abdeltawab

 

Workshop Team – Marwan Rouchdy, Mariam Abdel-Salam, Nada Kahla, Nadia Galal, Nada Ahmed, Mariam El-Nazer and Madaya Mahamat Nour

 

Guest Speaker – Dr. Mohamed Nagy (Children's Cancer Hospital Egypt 57357)

 

  PGx was defined 460 years before Christ: “It’s far more important to know what person the disease has than what disease the person has.” - Hippocrates (460 BC-370 BC)

 

Workshop Objectives

Provide an introduction to pharmacogenetics and pharmacogenomics and how patient genetics modulate variability in drug response with application in research and clinical settings.

 

Workshop Goals – an attempt to answer the following questions

·       Why does this drug work for you but not me?

·       Why do I have side effects and you don’t?

·       Why does someone need twice the standard dose to be effective?

·       Can we apply pharmacogenetics in the real world? In Egypt?

·       What is pharmacogenomics and is it different from pharmacogenetics?

·       Will today’s pharmacist be working with different drug labels, in Egypt?

 

Workshop Topics

·       Basic concepts of Genetic variation, Gene Polymorphisms, and SNP analysis

·       Pharmacogenomics and drug design in the post-genomic era

·       Pharmacogenetics databases and related resources – PharmGKB, ClinVar, dbSNP, CTD…etc.

·       Applied Pharmacogenomics in cancer, psychiatry, and infectious diseases

 

So Now, What is your excpectations?

 

Course content

  • Agenda

  • Background for Genomics Analyses

  • Databases Background

  • NCBI "how to" html guides - selected topics

  • Session 1 - Genetic Basis for Variability in Drug Response

  • Session 2 - Systems Biology and Holistic Approach to Understanding and Treating Complex Diseases

  • Session 3 - PGx & Drug Development in the Post-genomic Era

  • Session 4 - Genetic Variation Analyses Tools and Main Pharmacogenomics Database – PharmGKB Tutorial

  • PharmGKB resources

  • Session 5 - Application of PGx in infectious diseases

  • Session 6: PGx databases: Digging Deep

  • Session 7:  Application of PGx in Cancer

  • Session 8 and 10 - Hands on PharmGKB

  • Session 9 - Application of PGx in Psychiatric disorders

  • Session 11 - Ethical, Legal and Social Implications of Clinical Implementation of PGx

  • Session 12 - Concept Mapping

Interested? Enroll to this course right now.

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