Completed

Pharmacogenomics (PGx): the way to Personalized Medicine

Instructor

Nourtan Abdeltawab

Assistant Professor (Modaress)

Dr Nourtan Abdeltawab has more than 10 years’ experience in systems biology and genome-wide association studies (GWAS) of infectious diseases. She received her doctoral degree in systems biology of immunogenetics of infectious diseases from the University of Tennessee Health Science Center in Memphis, TN, USA in 2010 and continued postdoctoral training at the University of Cincinnati in Ohio, USA until 2012. Using GWAS she mapped quantitative trait loci (QTLs) modulating differential host responses to a number of infectious diseases including streptococcal sepsis, candidiasis, pneumonia, and Ebola. She has also worked on genome-wide transcriptional profiling projects, including mouse spleen (for more than 100 recombinant inbred mouse strains) and a human genome diversity cell line panel (CEPH panel). Dr Abdeltawab is currently L’Oréal-UNESCO FWIS fellow and Assistant Professor of microbiology and immunology, Cairo University, Faculty of Pharmacy.

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Overview

PGx defined 460 years before Christ

“It’s far more important to know what person the disease has than what disease the person has.”

- Hippocrates (460 BC-370 BC)

 

A two days intensive workshop on introduction to pharmacogenomics and personalized medicine

 

Workshop Objectives

Provide an introduction to concept and practice of pharmacogenetics and pharmacogenomics, by understanding genetic basis of variability in drug response with application in research and clinical settings.

Workshop Goals – an attempt to answer the following questions

Ø  Why does this drug work for you but not me?

Ø  Why do I have side effects and you don’t?

Ø  Why does someone need twice the standard dose to be effective?

Ø  Why do some people get cancer and chemotherapy works for them while others don’t?

Ø  Can we apply pharmacogenetics in real world?

Ø  Can we apply pharmacogenetics in Egypt?

Workshop Topics include

Ø  Basic concepts of Genetic variation, Gene Polymorphisms and SNP analysis

Ø  Pharmacogenomics and drug design in the post-genomic era

Ø  Pharmacogenetics databases and resources – CTD & PharmGKB databases

Ø  Applied Pharmacogenomics in cancer and selected diseases 

 

Workshop format – in-class discussions, hands-on tutorials, assignments.

Course content

  • Agenda

  • Background for Genomics Analyses

  • Databases Background

  • NCBI "how to" html guides - selected topics

  • Session 1 - Genetic Basis for Variability in Drug Response

  • Session 2 - Bioinfortmaics tools to study genetic variations

  • Session 3 - overview of pharmacodynamics, pharmacokinetics, dosing and toxicity -- PGx and PGt

  • Session 4 - Bioinformatics tools of PGx PharmGKB

  • PharmGKB resources

  • Session 5  Application of PGx in Cancer

  • Session 7 Application of PGt in HCV and other diseases

  • Session 8 - PGx in research settings (GWAS) and concluding remarks

Interested? Enroll to this course right now.

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